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NoteA suggested dose has been determined for each pediatric weight rangeRefer to Table 1Ensure all orders that specify a dose in milliliters include a concentrationbecause SUPRAX for oral suspension is available in three different concentrations100 mg/5 mL200 mg/5 mLand 500 mg/5 mL
SUPRAX tablets and suspensiongiven orallyare about 40to 50absorbed whether administered with or without foodhowevertime to maximal absorption is increased approximately 0.8 hours when administered with foodA single 200 mg tablet of cefixime produces an average peak serum concentration of approximately 2 mcg/mLrange 1 to 4 mcg/mLa single 400 mg tablet produces an average peak concentration of approximately 3.7 mcg/mLrange 1.3 to 7.7 mcg/mLThe oral suspension produces average peak concentrations approximately 25to 50higher than the tabletswhen tested in normal adult volunteersTwo hundred and 400 mg doses of oral suspension produce average peak concentrations of 3 mcg/mLrange 1 to 4.5 mcg/mLand 4.6 mcg/mLrange 1.9 to 7.7 mcg/mLrespectivelywhen tested in normal adult volunteersThe area under the time versus concentration curveAUCis greater by approximately 10to 25with the oral suspension than with the tablet after doses of 100 to 400 mgwhen tested in normal adult volunteersThis increased absorption should be taken into consideration if the oral suspension is to be substituted for the tabletBecause of the lack of bioequivalencetablets should not be substituted for oral suspension in the treatment of otitis mediasee DOSAGE AND ADMINISTRATIONCross-over studies of tablet versus suspension have not been performed in children.
In the treatment of infections due to Streptococcus pyogenesa therapeutic dosage of cefixime should be administered for at least 10 days.
Molecular weight507.50 as the trihydrateChemical Formula is C 16 H 15 N 5 O 7 S 23H 2 O.
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